My continuing debate with organic chemists about 13C NMR
I have a continuing discussion with synthetic organic post-docs
and grad students regarding efficient use of instrument time.
When I explain that it is just as valid to extract 13C chemical
shifts from HMQC and HMBC experiments as it is from 1D 13C spectra
they first look puzzled, then they agree with me, but ultimately
they say that even though they agree with me, thesis committees
and journal referees expect them to run the traditional 13C spectrum.
Now I am the first to admit there are probably plenty of situations
where the 1D 13C is useful and even necessary. But I also believe
that in most cases, if the HMQC and HMBC have been run, and the
molecular weight is known from mass spec, then a 1D 13C is simply a
very expensive formality.
So here is my question:
"For a particular compound, if all of the 13C chemical shifts can be
identified from a combination of HMQC (or HSQC) and HMBC, shouldn't
the organic chemistry community accept that a 1D 13C spectrum is
unnecessary?"
With your permission I will redistribute some of the more interesting
responses.
Thanks in advance.
Don
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Donald M. Leek
Chemical Biology NMR Laboratory
Steacie Institute for Molecular Sciences
National Research Council Canada
Ottawa, Canada K1A 0R6
phone: (613) 993-6356
fax: (613) 952-0068
email: don.leek@nrc.ca
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