I think that your presumption that "1D 13C is simply a very expensive
formality", may be weak. 1D DEPT45 is as efficient as any 2D inverse
detection method, in my experience, except possibly for the detection of
quaternary carbon. There may be problems in 2D that can be resolved in 1D.
See for example "100 and More Basic NMR Experiments" by Stefan Berger.
----- Original Message -----
From: "Leek, Don" <Don.Leek@nrc.ca>
To: <bruker-users-mail@purcell.cchem.berkeley.edu>
Sent: Tuesday, November 27, 2001 1:20 PM
Subject: My continuing debate with organic chemists about 13C NMR
>
> My continuing debate with organic chemists about 13C NMR
>
> I have a continuing discussion with synthetic organic post-docs
> and grad students regarding efficient use of instrument time.
> When I explain that it is just as valid to extract 13C chemical
> shifts from HMQC and HMBC experiments as it is from 1D 13C spectra
> they first look puzzled, then they agree with me, but ultimately
> they say that even though they agree with me, thesis committees
> and journal referees expect them to run the traditional 13C spectrum.
> Now I am the first to admit there are probably plenty of situations
> where the 1D 13C is useful and even necessary. But I also believe
> that in most cases, if the HMQC and HMBC have been run, and the
> molecular weight is known from mass spec, then a 1D 13C is simply a
> very expensive formality.
>
> So here is my question:
>
> "For a particular compound, if all of the 13C chemical shifts can be
> identified from a combination of HMQC (or HSQC) and HMBC, shouldn't
> the organic chemistry community accept that a 1D 13C spectrum is
> unnecessary?"
>
> With your permission I will redistribute some of the more interesting
> responses.
>
> Thanks in advance.
>
> Don
>
> ***********************************
> Donald M. Leek
> Chemical Biology NMR Laboratory
> Steacie Institute for Molecular Sciences
> National Research Council Canada
> Ottawa, Canada K1A 0R6
> phone: (613) 993-6356
> fax: (613) 952-0068
> email: don.leek@nrc.ca
> ***********************************
>
>
>
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