Protein NMR Spectroscopist
Salary: $A39,053 - 42,096
A two-year postdoctoral position is available immediately to
determine the NMR structure of various proteins within the Protein
Structure Group at Macquarie University, Sydney. The successful
applicant will primarily work to define aprotein fold thought to be
representative of a new family of cell-cell adhesionmolecules.
Spectra obtained to date on this surface glycoprotein (MW=15kDa)
are of very high quality (Zachara et al., Eur. J. Biochem. 238, 511-
518, 1996) and milligram quantities of the 15N-labelled recombinant
protein are routinely prepared in this laboratory.
The Protein Structure Group is focussed on several proteins involved
in cellular adhesion and regulation. It is staffed by a
multidisciplinary team encompassing molecular biology, protein
expression and NMR structure determination. We are a component
of the Macquarie University Centre for Analytical Biotechnology, and
are closely associated with the Australian Proteome Analysis Facility,
which together form the major centre for protein research in the
Sydney region. The Group is also part of IBiS (Initiative in
Biomolecular Structure), a multidisciplinary forum addressing NMR,
crystallography and computer techniques in structural biology.
A new 600 MHz NMR spectrometer will be installed in the School of
Chemistry in 1997. In the interim, generous access to a DMX-600
spectrometer (with pulse-field gradient capability) is available nearby
at the University of New South Wales. Other resources include state-
of-the art protein purification and analysis equipment, and a cluster
of dedicated Silicon Graphics workstations.
Applicants should have a Ph.D. in Chemistry, Biochemistry or
related field. Experience in the recording and analysis of
heteronuclear multidimensional NMR spectra of biomolecules is
essential, as is familiarity with UNIX and NMR processing packages.
Appointment is available immediately, initially until December 1997,
and is renewable subject to grant funding. Applications close March
7, 1997.
For further information concerning applications contact:
Dr Bridget Mabbutt, School of Chemistry,
email: bridget.mabbutt@mq.edu.au,
telephone: (61 2) 9850 8282,
fax: (61 2) 9850 8313