The preparation and characterization (by melting point) of a solid derivative is to be used for verification of the structure of the unknown. The use of higher field ¹H or ¹³C nmr spectroscopy or mass spectrometry to aid in the identification of these compounds is not permitted.

Unknown #2 is more challenging, and will be handed out in smaller quantities (~60 mg). Each student in the course will be assigned to a 4th year undergrad or graduate student in the Department, who will measure the high-field ¹H and ¹³C nmr spectra of the compound, using a sample prepared by the student. Students are expected to be present during the recording of these spectra. The sample will then be submitted to the Departmental Mass Spectrometry facility for determination of the mass spectrum. The compound should be solvable on the basis of these data.

The unknowns are to be identified in a short report submitted to the T.A.. The report is to include copies of all spectral data, and a short written section interpreting the spectra and explaining the logic employed to solve the structures.

04feb97; wjl