Free University of Brussels (VUB)
High Resolution NMR Centre
****Postdoc position available****
The High resolution NMR centre (HNMR) of the Vrije Universiteit Brussel (=
VUB)
has a post-doctoral position available in biomolecular NMR for at least 1=
year,
up to maximum 4 years, starting October 1st , 1997. The biomolecular NMR
research
activities in this interfacultary NMR department were initiated in 1994 a=
nd
involve the study of chitin binding proteins, and their interactions with=
model
oligomer carbohydrates. These studies are now being extended to determine=
the
determinants of protein carbohydrate interactions by using naturally occu=
ring
isoforms, having suitable amino acid substitutions in the sugar binding s=
ite.
For this purpose, chitin oligomers, selectively enriched in 13C are also =
being
synthesized, and will soon be available within the unit. On the short ter=
m, the
HNMR centre is also initiating multinuclear NMR studies on 15N and 13C/15=
N
label
led proteins, involved in bacterial resistance against heavy metals.
The instrumentation of the HNMR centre consists of a three channel Bruker=
AMX
500 MHz spectrometer, fully equipped for biomolecular NMR applications,
including B0
gradients, digital lock, and all necessary probes. A DRX 250 MHz with the=
same
facilities is forthcoming, together with further upgrades for the AMX500.=
The
NMR
centre has access to a Varian Unity 600 MHz at a neighbouring research ca=
mpus.
The HNMR centre is closely collaborating with the Ultrastructure departme=
nt
(Prof. Dr. L. Wyns) of the Institute of Molecular Biology of the VUB, whi=
ch
houses
X-ray diffraction, calorimetric and CD spectroscopy facilities, allowing
optimal
structural and physicochemical characterisation of the systems of interes=
t.The
successfull applicant will have obtained a Ph.D in the field of biomolecu=
lar
NMR,
and is expected to have demonstrated abilities to carry out and publish
original
and high standard research. The applicant is expected to vintegrate the
resources
of the Varian 600 MHz into the HNMR centre=92s research. Therefore, exper=
ience
with
Varian spectrometers is required. Experience with expression and purifica=
tion
of
proteins in labelled media would be an advantage but are not a prerequisi=
te.
Applications should be sent to Dr. Jos=E9 C. Martins at the following add=
ress:
HNMR centre (ORGC),
Vrije Universiteit Brussel,
Pleinlaan 2, B-1050 Brussel,
Belgium.
More information can be obtained informally by e-mail to jose@hnmr.vub.a=
c.be,
or by phone at ++32-2-629-33-05.
-- =
Jose Martins Ph.D
High Resolution NMR Centre
HNMR (ORGC)
Vrije Universiteit Brussel
Pleinlaan 2, B-1050 Brussel
phone: 32-2-629-33-05
fax : 32-2-629-32-81
e-mail jose@hnmr.vub.ac.be
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