POSTDOCTORAL RESEARCH ASSOCIATE:
The research includes
determination of the three-dimensional conformation and dynamics of
of complex polysaccharides and oligosaccharides from pathogenic
bacteria. Practical applications of the research are related to
development of bacterial polysaccharide vaccines.
Methods will emphasize heteronuclear multidimensional
NMR spectroscopy including measurement of scalar and dipolar
coupling of <sup>15</sup>N and <sup>13</sup>C enriched samples. Analysis
will require
computer molecular modeling and molecular dynamics simulation.
Excellent NMR instrumentation and computer facilities are available
including spectrometers at 500, 600 and 800 MHz including a recenty
purchased high-sensitivity cryoprobe.
The NMR methods available exploit heteornuclear scalar coupling as well
as residual dipolar coupling in solutions weakly oriented by liquid
crystals. A scheme for enrichment in <sup>13</sup>C (or <sup>15</sup>N
) for
cell wall polysaccharides from viridans streps and also for the
capsular polysaccharides of
<i>vibrio cholerae</i> provides a source of biologically
active polysaccharides and oligosaccharides for these NMR
experiments. Recently developed
methods for computer molecular modeling will be
combined with molecular dynamics simulation for interpretataion
of the NMR data.
Appointments are made for a period
of one year but are renewable by mutual agreement.
For reprints of recent papers,
see: http://www.research.umbc.edu/~bush/
Candidates should send C.V.
and three letters of recommendation to C. Allen Bush,
Department of Chemistry and Biochemistry,
University of Maryland Baltimore County,
1000 Hilltop Circle, Baltimore, MD 21250
- bush@umbc.edu
**************mail from:
Prof. C. Allen Bush, Dept. of Chemistry, Univ. Maryland Baltimore County,
1000 Hilltop Circle; Baltimore, MD 21250. e-mail: bush@umbc.edu
website: http://www.research.umbc.edu/~bush/
phone: (410) 455-2506 fax: (410) 455-2608
**************
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