Group Publications

Citation indices	All	Since 2014
Citations	4746	1800
h-index	40	23
i10-index	98	61

147. Synthesis of α-methylstilbenes using an aqueous Wittig methodology and application toward the development of potent human aromatase inhibitors. A. J. Nielsen, S. Ráez-Villanueva, D.J. Crankshaw, A. Holloway, J McNulty,* Bioorg. & Med. Chem. Lett., 29, in press (2019).

146. Polyphenolic Natural Products and Natural Product-Inspired Steroidal Mimics as Aromatase Inhibitors. A. Nielsen, J. McNulty,* Medic. Res. Rev., in press (2019): 10.1002/med.21536

145. Chemoenzymatic synthesis of the Antifungal Compound (-)-Pestynol via a Convergent, Sonogashira Construction of the Central Yne-diene. S. Borra, M. Kumar, J McNulty,* D. Baidilov, T. Hudlicky,* Eur. J. Org. Chem., 77-79 (2019).

144. R430: A potent inhibitor of DNA and RNA viruses. L D'Aiuto, J. McNulty, C Hartline, M. Demers, R. Kalkeri, J. Wood, L. McClain, A. Chattopadhyay, Y. Zhi, J. Naciri, A. Smith, R. Yolken, K Chowdari, C. Zepeda-Velazquez, C. B Dokuburra, E Marques, R. Ptak, P. Kinchington, S. Watkins, M. Prichard, D. Bloom, V. Nimgaonkar. Scientific Reports, 8, 16662 (2018).

143. Asymmetric entry to 10b-aza-analogues of Amaryllidaceae akaloids reveals a pronounced electronic effect on antiviral activity. C. Brown, T. Kong, J. Britten, N. H. Werstiuk, J. McNulty,* L. D'Aiuto, M. Demers, V. Nimgaonkar, ACS Omega, 3, 11469-11476 (2018).

142. Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine. S. Borra, R. Lapinskaite, C. Kempthorne, D. Liscombe, J. McNulty,* T. Hudlicky, J. Nat. Prod. 81, 1451-1459 (2018).

141. Generation of Three-dimensional Human Neuronal Cultures for Modeling CNS Viral Infections. L. D'Aiuto,* J. N Naciri, N. Radio, S. Tekur, D. Clayton, G. L. Apodaca, R. Di Maio; Y. Zhi, P. Dimitrion, P. Piazza, M. Demers, J. Wood, C. T. Chu, J. Callio, L. McClain, R. Yolken, J. McNulty, P. Kinchington, D. C. Bloom, V. L. Nimgaonkar. Stem Cell Research & Therapy, 9, 134, (1-9) (2018).

140. One-pot, Multicomponent Synthesis of 2,3-Disubstituted Quinazolinones with Potent and Selective Activity Against Toxoplasma gondii. C. E. Brown, T. Kong, C. Bordon, R. Yolke, L. Jones-Brando, J. McNulty,* Bioorg. & Med. Chem. Lett., 28, 1642-1646 (2018).

139. Three new Polyketides from Fruiting Bodies of the Endophytic ascomycete Xylaria polymorpha. C. E. Brown, D. Liscombe, J. McNulty,* Nat. Prod. Res., 32, 2408-2417 (2018).

138. Discovery of Potent Antiviral (HSV-1) Quinazolinones and Initial Structure-Activity Relationship Studies. C. E. Brown, T. Kong, J. McNulty,* L. D’Aiuto, P. Piazza, K. Williamson, L. McClain, V. Nimgaonkar,* Bioorg. & Med. Chem. Lett., 27, 4601-4605, (2017).

137. Regioselective Ylide Formation on Acetal-Functionalized Trialkyl Phosphonium Salts: Extending the Scope of Carbonyl-Homologation. A. Narayanappa, D. Hurem, J. McNulty,* Synlett, 28, 2961-2965 (2017).

136. Comparison of three cell-based drug screening platforms for HSV-1 infection. L. D’Aiuto, Y. Zhi, L. McClain, J. McNulty, C. E. Brown, A. J. Nielsen, M. B. Yee, P. Piazza, R. H. Yolken, P. R. Kinchington, V. L. Nimgaonkar,* Antiviral Research, 142, 136-140 (2017).

135. Structurally Simplified Biphenyl Combretastatin A4 Derivatives Retain In Vitro Anti-Cancer Activity Dependent on Mitotic Arrest. D. Tarade, D. Ma, F. Mansour, C. Pignanelli, J. Gauld, S. van den Berg, J. McNulty, S. Pandey, PLOS ONE, 1293, e0171806, (2017).

134. Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III. D. Ma, C. Pignanelli, D. Tarade, T. Gilbert, M. Noel, F. Mansour, S. Adams, A. Dowhayko, K. Stokes, S. Vshyvenko, T. Hudlicky, J. McNulty, S. Pandey,* Nature: Scientific Reports, 7, 42957 (2017).

133. Total Enantioselective Synthesis of the Endophytic Fungal Polyketide Phomolide H and its Structural Revision. J. McNulty*, D. Mcleod, Eur. J. Org. Chem. 29-33, (2017).

132. Stereoselective preparation of Stilbenes Employing Trialkylphosphoranylides: New Methods and Applications, in Stilbene: Derivatives, Applications and Research, Nova Science, D. McLeod, J. McNulty,* pp. 1-22, (2017).

131. Synthetic Approaches to the Naturally Occuring Anticancer Amaryllidaceae Alkaloids trans-dihydrolycoricidine and trans-dihydronarciclasine. C. Zepeda-Velázquez, J. McNulty*,

Stud. Nat. Prod. Chem., 53, 85-108 (2017).

130. Review of Cytotoxic CA4 Analogues That do Not Target Microtubules: Implications For CA4 Development. D. Tarade, S. Pandey*, J. McNulty, Mini-Rev. Med. Chem., 17, 1507-1514 (2017).

129. Total Synthesis of the Natural Product (+)-trans-Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]-Cycloaddition discovery of its potent anti-Zika Virus (ZIKV) Activity. O. Revu, C. Zepeda-Velazquez, A. Nielsen, J. McNulty*, R. H. Yolken, L. Jones-Brando, ChemistrySelect, 1, 5895-5899 (2016).

128. DualPhos: a versatile, chemoselective reagent for two-carbon aldehyde to latent alkenal homologation application in the total synthesis of phomolide G. D. Mcleod, J. McNulty*, Roy. Soc. Open Sci. 3, 160374 (2016).

127. Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity. C. E. Brown, J. McNulty, L. Jones-Brando, Org. Biomolec. Chem., 14, 5951-5955 (2016).

126. Asymmetric Organocatalytic Stepwise [2+2] Entry to Tetrasubstituted Heterodimeric and Homochiral Cyclobutanes. A. J. Nielsen, H. A, Jenkins, J. McNulty, Chem. Eur. J. 22, 9111-9115 (2016).

125. Enantioselective Total Synthesis of the Proposed Structure of the Endophytic Fungal Metabolite Phomolide G: Structural Revision and Unambiguous Stereochemical Assignment. J. McNulty*, D. McLeod, H. A. Jenkins, Eur. J. Org. Chem. 688-692 (2016).

124. iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore With Multiple Effects Against Herpesvirus Infections. J. McNulty*, L. D’Aiuto, Y. Zhi, L. McClain, C. Zepeda-Velázquez, S. Ler, H. A.. Jenkins, M. B. Yee, P. Piazza, R. H. Yolken, P. R. Kinchington, V. L. Nimgaonkar*, ACS Med. Chem. Lett., 7, 46-50 (2016).

123. Tris(3-hydroxypropyl)phosphine (THPP): A Mild, air-stable reagent for the rapid, reductive cleavage of small-molecule disulfides. J. McNulty*, V. Krishnamoorthy, D. Amoroso, M. Moser, Bioorg. & Med. Chem. Lett., 25, 4114-4117 (2015).

122. Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii. J. McNulty*, K. Keskar, H.A. Jenkins, N. H. Werstiuk, C. Bordon, R.Yolken, L. Jones-Brando., Org. Biomolec. Chem., 13, 10015-10024 (2015).

121. Antimitotic activity of structurally simplified biaryl analogs of the anticancer agents colchicine and combretastatin-A4. J. McNulty*, S. van den Berg; D. Ma; D. Tarade; S. Joshi; J. Church, S.Pandey, Bioorg. & Med. Chem. Lett., 25, 117-121 (2015).

120. 120. Wittig Reactions of Trialkylphosphine-derived Ylides: New Directions and Applications in Organic Synthesis. J. McNulty*, D. McLeod, P. Das, C. Zepeda-Velázquez, Phosphorus. Sulfur, Silicon & Relat. Elements., 190, 619-632 (2015).

119. Discovery of a new class of cinnamyl-triazole as potent and selective inhibitors of aromatase. J. McNulty*, K. Keskar, A. Holloway, D. Crankshaw, Bioorg. & Med. Chem. Lett., 24, 4586-4589 (2014).

118. Enantioselective Organocatalytic Michael-aldol Sequence to the Anticancer Natural Product (+)-trans-dihydrolycoricidine. J. McNulty*, C. Zepeda-Velazquez, Angew. Chem. Int. Ed. 53, 8450-8454 (2014). See also: Short Synthesis of a Wildflower Alkaloid, Chem. & Eng. News, July 7th, 2014, p. 28-29. See also: Synfacts, 10, 982 (2014).

117. Total Synthesis of the Cyanobacterial Metabolite Nostodione A: Discovery of its Antiparasitic Activity Against Toxoplasma gondii. J. McNulty*, K. Keskar, C. Bordon, R. Yolken, L. Jones-Brando, J. Chem. Soc., Chem. Commun. 50, 8904-8907 (2014).

116. High Yielding Synthesis of Carboranes Under Mild Conditions Using a Homogeneous Silver(I) Catalyst. Direct Evidence of a Bimetallic Intermediate. M. E. El-Zaria, K. Keskar, A. R. Genady, J. A. Ioppolo, J. McNulty, J. F. Valliant*, Angew. Chem. Int. Ed. 53, 5156-5160 (2014). See also: Synfacts, 10, 585 (2014).

115. A robust, well defined homogeneous silver(I) catalyst for mild intramolecular hydroamination of 2-ethynylanilines leading to indoles. J. McNulty*, K. Keskar, Eur. J. Org. Chem. 1622-1629 (2014).

114. Synthesis and anti-toxoplasmosis activity of 4-arylquinoline-2-carboxylate derivatives. J. McNulty*, R. Vemula, C. Bordon, R. Yolken, L. Jones-Brando, Org. Biomolec. Chem., 12, 255-260 (2014).

113. Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water.
J. McNulty*, C. Zepeda, D. McLeod, Green Chemistry, 15, 3146-3149 (2013).

112. A scalable process for the synthesis of (E)-pterostilbene involving aqueous Wittig olefination chemistry. J. McNulty*, D. McLeod, Tetrahedron Lett., 54, 6303-6306 (2013).

111. Investigation of aryl halides as ketone bioisosteres: refinement of potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). J. McNulty*, A. J. Nielsen, C. E Brown, B. R. Difrancesco, N. Vurgun, J. J. Nair; D. Crankshaw, A. Holloway, Bioorg. & Med. Chem. Lett., 23, 6060-6063 (2013).

110. Tandem oxidative radical fragmentation-rearrangement of 2-amino-1,3-benzylidene acetals: A short entry to densely functionalised fully differentiated oxazolidinones. J. McNulty*, J. Calzavara, RSC Advances, 3, 6771-6774 (2013).

109. Phthalide: a direct building-block towards P,O and P,N hemilabile ligands: Application in the palladium-catalysed Suzuki-Miyaura cross-coupling of aryl chlorides. J. McNulty*, K. Keskar, Org. Biomolec. Chem., 11, 2404-2407 (2013).

108. Mild chemical and biological synthesis of donor-acceptor flanked reporter stilbenes: Demonstration of a physiological Wittig olefination reaction. J. McNulty*, D. McLeod, Eur. J. Org. Chem. 6127-6131 (2012).

107. Discovery of a robust and efficient homogeneous silver(I) catalyst for the cycloaddition of azides onto terminal alkynes. J. McNulty*, K. Keskar, Eur. J. Org. Chem. 5462-5470 (2012).

106. One-Step Synthesis of Reusable, Polymer-Supported Tri-alkyl Phosphine Ligands. Application in Suzuki-Miyaura and Alkoxycarbonylation Reactions. E. Ullah, J. McNulty*, M. Sliwinski, A. Robertson, Tetrahedron Lett., 53, 3990-3993 (2012).

105. The phosphate-carboxylate mixed-anhydride method: A mild, efficient process for ester and amide bond construction. J. McNulty*, R. Vemula, V. Krishnamoorthy, , A. Robertson, Tetrahedron, 68, 5415-5421 (2012).

104. Highly Chemoselective Mono Suzuki Arylation Reactions on all three Dichlorobenzene isomers and Applications Development. E. Ullah, J. McNulty*, A. Robertson, Eur. J. Org. Chem., 2127-2131 (2012).

103. Synthesizing novel anthraquinone natural product-like compounds to investigate protein-ligand interactions in both an in vitro and in vivo assay. J. McNulty*, N. McKenzie*, D. McLeod, M. McFadden, N. Balachandran, J. Chem. Ed., 89, 743-749 (2012).

102. Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase). J. McNulty*, J. J. Nair, N. Vurgun, B. DiFrancesco, C. Brown, A. Holloway, D. Crankshaw, B. Tsoi, Bioorg. & Med. Chem. Lett., 22, 718-722 (2012).

101. A Novel Synthetic C1 Analog of 7-deoxypancratistatin Induces Apoptosis in p53 Positive and Negative Human Colorectal Cancer Cells by Targeting the Mitochondria: Enhancement of Activity by Tamoxifen. D. Ma, P. Tremblay, K. Mahngar, P. Akbari-Asl, J. Collins, T. Hudlicky, J. McNulty, S. Pandey*, Investig. New Drugs, 30, 1012-1027 (2012).

100. The first well-defined silver(I)-complex catalyzed cycloaddition of azides onto terminal alkynes at room temperature. J. McNulty*, K. Keskar, R. Vemula, Chem. Eur. J. 17, 14727-14730 (2011).

99. A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry, J. Calzavara, J. McNulty*, Tetrahedron Lett., 52, 5672-5675 (2011).

98. A Tandem “on Palladium” Heck-Jeffery-amination Route toward the Synthesis of Functionalized Indole-2-carboxylates. J. McNulty*, K. Keskar, Eur. J. Org. Chem., 6902-6908 (2011).

97. Amine and sulfonamide promoted Wittig olefination reactions in water. J. McNulty*, D. Mcleod, Chem. Eur. J. 17, 8794-8798 (2011).

96. An iterative approach toward the synthesis of discrete oligomeric p-phenylene vinylene organic dyes employing aqueous Wittig chemistry. J. McNulty*, D. McLeod, Tetrahedron Lett., 52, 5467-5470 (2011).

95. One Step Entry to P,O- and P,N-type Heterocyclic Tertiary Phosphine Ligands and Application in Suzuki-Miyaura Cross-coupling Reactions. E. Ullah, J. McNulty*, A. Robertson, C. Kennedy, Org. Biomolec. Chem., 9, 4421-4424 (2011).

94. Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. I. B. Wenderska, M. Chong, J. McNulty, G. D. Wright, L. L. Burrows*, Chem. Bio. Chem. 12, 2759-2666 (2011).

93. Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells. C. Griffin, J. McNulty, S. Pandey*, Int. J. Oncol., 38, 1549-1556 (2011).

92 .Discovery of an Acid-promoted [3+2] Cyclodimerization of 3-Vinylindoles and the Development of a General Lewis Acid-catalyzed Process. J. McNulty*, D. McLeod, Synlett, 717-721 (2011).

91. Human Cytochrome P450 Liability Studies of trans-Dihydronarciclasine: A Readily Available, Potent and Selective Cancer Cell Growth Inhibitor. J. McNulty*, A. Thorat, N. Vurgun, J. J. Nair, E. Makaji, D. J. Crankshaw, A. C. Holloway, S. Pandey, J. Nat. Prod., 74, 106-108 (2011).

90. A Direct Synthesis of Functionalized Styrenes and Terminal 1,3-dienes via Aqueous Wittig Chemistry with Formalin. P. Das, D. Mcleod, J. McNulty*, Tetrahedron Lett., 52, 199-201 (2011).

89. Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. C. Griffin, J. McNulty, S. Pandey*, Molec. Cancer Therap., 10, 57-68, (2011).

88. Sensitization of human melanoma cells by tamoxifen to apoptosis induction by Pancratistatin, a non-genotoxic natural compound. S. J. Chatterjee, J. McNulty, S. Pandey*, Melanoma Research, 21, 1-11 (2011).

87. P-Phenyl-2,2,6,6-tetramethylphosphorinan-4-ol: An air-stable P,O-type ligand for palladium-mediated cross-coupling reactions. E. Ullah, J. McNulty*, V. Larichev, A. Robertson, Eur. J. Org. Chem. 6824-6830 (2010).

86. A Sol-Gel Derived Acetylcholinesterase Microarray for Nanovolume Small Molecule Screening. M. Monton, J. Lebert, J. Little, J. J. Nair, J. McNulty, J. Brennan*, Analytical Chem. 82, 9365-9373 (2010).

85. Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids. J. McNulty*, J. J Nair; J. D. Brennan; J. R. Little. Bioorg. & Med. Chem. Lett., 20, 5290-5294 (2010).

84. Cytochrome P450 3A4 Inhibitory Studies Within the Lycorane Class of Amaryllidaceae Alkaloids. J. McNulty*, J. J Nair; M. Singh; D. Crankshaw, A. Holloway, Nat. Prod. Comm. 5, 1195-1200 (2010).

83. Dichotomous reactivity in the reaction of triethyl- and triphenylphosphane HBr salts with dimethyl acetals. A novel entry to α-alkoxy-functionalized ylides and general synthesis of vinyl ethers and alkoxy dienes. P. Das, J. McNulty*, Eur. J. Org. Chem., 3587-3591 (2010).

82. Discovery of a novel pharmacophore having potent and selective inhibition of human aromatase, cytochrome P450 CYP19. J. McNulty*, J. J. Nair, A. C. Holloway, D. J. Crankshaw. United States Provisional Patent, 61/392,220 filed October 12, 2010.

81. A short synthesis of the anti-leukemic sesquiterpene (+)-caparratriene employing aqueous Wittig chemistry. P. Das, J. McNulty*, Tetrahedron Lett., 51, 3199-3201 (2010).

80. Microwave-assisted aqueous Wittig reactions: Chemoselective, organic solvent and protecting group-free synthesis of functionalized alkenes. J. McNulty*, P. Das, D. McLeod., Chem. Eur. J. 16, 6756-6760 (2010).

79. Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells. C. Griffin, C. Hamm, J. McNulty and S. Pandey*. Cancer Cell International, 10 (6), 1-7 (2010).

78. Potent and selective inhibiton of human cytochrome P450 3A4 by seco-pancratistatin structural analogs. J. McNulty*, J. J Nair; M. Singh; D. Crankshaw, A. Holloway Bioorg. & Med. Chem. Lett., 20, 2335-2339 (2010).

77. Isolation of Flavonoids from the Heartwood and Resin of Prunus avium and some preliminary biological investigations. J. McNulty, J. J. Nair, E. Bollareddy, K. Keskar, A. Thorat, D. J. Crankshaw, A. Holloway, G. Khan, G.D. Wright, L. Ejim, Phytochemistry, 70, (2009).

76. Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4. J. McNulty, J. J. Nair, M. Singh, D. J. Crankshaw, A. C. Holloway, Bioorg. & Med. Chem. Lett., 19, (2009).

75. Aqueous Wittig reactions of semi-stabilized ylides. A straightforward synthesis of 1,3-dienes and 1,3,5-trienes. J. McNulty, P. Das, Tetrahedron Lett., 50, 5737 (2009).

74. A Novel P,O-type phosphorinane ligand for the Suzuki-Miyaura cross-coupling of aryl chlorides. E. Ullah, J. McNulty, A. Robertson, Tetrahedron Lett., 50, 5599 (2009).

73. Development of a one-pot method for the homologation of aldehydes to carboxylic acids. J. McNulty, P. Das, Tetrahedron, 65, 7794 (2009).

72. Highly stereoselective and general synthesis of trans-stilbenes and alkenes by means of an aqueous Wittig reaction. J. McNulty, P. Das, Eur. J. Org. Chem., 4031 (2009)

71. Selective Cytochrome P450 3A4 Inhibitory Activity of Amaryllidaceae Alkaloids. J. McNulty, J. J. Nair, M. Singh, D. J. Crankshaw, A. C. Holloway, J. Bastida, Bioorg. & Med. Chem. Lett., 19 3233 (2009).

70. Structure-activity Studies on the Lycorine Pharmacophore: A Potent Inducer of Apoptosis in Human Leukemia Cells. J. McNulty, J. J. Nair, J. Bastida, S. Pandey, C. Griffin, Phytochemistry, 70, 913 (2009).

69. Highly Stereoselective and General Synthesis of trans-Stilbenes, Alkenes and Conjugated Polyenes. J. McNulty, P. Das. United States Provisional Patent 61-167,960, filed, April 9th, (2009).

68. A Synthesis of Sulfonamide Analogues of Platensimycin Employing a Palladium-mediated Carbonylation Strategy. J. McNulty, J. J. Nair, A. Capretta, Tetrahedron Lett., 50, 4087 (2009).

67. Efficient palladium-catalysed carbonylative and Suzuki-Miyaura cross coupling reactions with bis(di-tert-butylphosphino)-o-xylene. J. McNulty*, J. J. Nair, M. Sliwinski,Tetrahedron Lett., 50, 2342-2346 (2009).

66. Structure Activity Studies on the Crinane Alkaloid Apoptosis-inducing Pharmacophore. J. McNulty*, J.J. Nair, S. Pandey, C. Grffin. Nat. Prod. Comm. 4, 483-488 (2009).

65. Stereoselective Wittig Olefination Reactions Employing a Novel ortho-P-Aryl Alkoxide Effect. J. McNulty, K. Keskar, Tetrahedron Lett., 49, 7054 (2008).

64. A Direct Synthesis of Vinylphosphonium Salts from alpha-Trimethylsilyl Ylides and Non-enolizable Aldehydes. J. McNulty, P. Das, Chemistry, A European Journal, 14, 8469-8472 (2008).

63. Direct formation of esters and amides from carboxylic acids using diethyl chlorophosphate in pyridine. J. McNulty, V. Krishnamoorthy, , A. Robertson , Tetrahedron Lett., 49, 6344-6347 (2008).

62. Rapid and efficient entry to vinylsilanes from aldehydes employing a novel transmetalation-Peterson sequence. J. McNulty, P. Das, J. Chem. Soc., Chem. Comm., 1244 (2008).

61. Synthesis and Biological Evaluation of Fully Functionalized seco-Pancratistatin Analogues. J. McNulty, J.J. Nair, C. Griffin, S. Pandey, J. Nat. Prod., 71, 357 (2008).

60. An improved synthesis of alpha-phosphonoenamines based on a modified Peterson olefination. J. McNulty, P. Das, D. Gosciniak, Tetrahedron Lett. 49, 281 (2008).

59. Synergy of Pancratistatin and Tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. P. Siedlakowski, A. McLachlan, C. Griffin, J. McNulty, S. Pandey, Cancer Biol. and Therap., 7, 376-384 (2008).

58. Unusual Magnesium Chloride Catalyzed non-Evans anti-Aldol reactions on an Enolizable L-Threose Derivative. J. McNulty, J.J. Nair, M. Sliwinski, L.E. Harrington, S. Pandey, Eur. J., Org. Chem., 5669 (2007).

57. Efficient Carbonylation Reactions in Phosphonium Salt Ionic Liquids: Anionic Effects. J. McNulty,* J.J. Nair, A.J. Robertson, Organic Lett., 9, 4575 (2007).

56. Discovery of the apoptosis-inducing activity and high accumulation of the butenolides Menisdaurilide and Aquilegiolide in Dicentra spectablis. J. McNulty,* J. J. Nair, J. Poloczek, N. H.Werstiuk, S. Pandey, Planta Medica, 73, 1543 (2007).

55. Selective Cytotoxicity of Pancratistatin-related Natural Amaryllidaceae Alkaloids: Evaluation of the Activity of Two New Compounds. C. Griffin, N. Sharda, D. Sood, J. J. Nair, J. McNulty, S. Pandey,* Cancer Cell. Internat., 1-7 (2007).

54. Selective Apoptosis-inducing activity of Crinum-type Amaryllidaceae alkaloids J. McNulty,* J.J. Nair, C. Codina, J. Bastida, S. Pandey, J. Gerasimoff, C. Griffin, Phytochemistry, 68, 1068 (2007).

53. A Pronounced Anionic Effect in the Pd-catalyzed Buchwald-Hartwig Amination Reaction Revealed in Phosphonium Salt Ionic Liquids. J. McNulty,* S. Cheekoori, T.P. Bender, J.A. Coggan, Eur. J. Org. Chem., 1423 (2007).

52. Activation of membrane-Fas-receptor associated caspase-3 and induction of apoptosis by Pancratistatin, a novel anti-cancer agent capable of selectively targeting leukemia cells. Carly Griffin, James McNulty, Caroline Hamm, and Siyaram Pandey, Apoptosis Cell Res. 93-109 (2007).

51. Scope and Mechanistic Insights Into the use of Trihexyl(tetradecyl)phosphonium Bistriflimide: a Remarkably Selective Ionic Liquid Solvent for Substitution Reactions. J. McNulty,* J.J. Nair, S. Cheekoori, V. Larichev, A. Capretta,A.J. Robertson, Chemistry, A European Journal, 12, 9314 (2006).

50. Phosphorinanes as Ligands for Palladium-Catalyzed Cross-Coupling Chemistry. T. Brenstrum, J. Clattenburg, J. Britten, S. Zavorines, J. Dyck, A.J. Robertson, J. McNulty,* A. Capretta,* Organic Lett., 8, 103 (2006).

49. A Synthesis of 3-deoxy-dihydro-lycoricidine: Refinement of a Structurally Minimum Pancratistatin Pharmacophore. J. McNulty, V. Larichev, S. Pandey, Bioorganic and Med. Chem. Lett., 15, 5315 (2005).

48. Application of Phosphonium Salts as Catalysts. J. McNulty, Multiphase Homogeneous Catalysis, Vol. 2, pp 542-6, Wiley-VCH Pub., Weinheim, (2005).

47. Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. A.M. McLachlan, N. Kekre, J. McNulty, S. Pandey, Apoptosis, 10, 619 (2005).

46. Induction of Apoptotic Cell Death Specifically in Rat and Human Cancer Cells by Pancratistatin. S. Pandey,* N. Kekre, J. McNulty, J. Naderi, Art. Cells, Blood Sub. & Biotech., 33, 279 (2005).

45. A Mild Esterification Process in Phosphonium Salt Ionic Liquid. J. McNulty,* S. Cheekoori, J.J. Nair, V. Larichev., A. Capretta, A.J. Robertson, Tetrahedron Lett., 46, 3641 (2005).

44. Dimethylmalonyltrialkylphosphoranes: Probing the steric effect on phosphorus and its stereochemical consequence in esterification reactions of chiral secondary alcohols. J.Dyck, J.McNulty,* A.Capretta, V.Larichev, S.Zavorine, A.Robertson, J. Organomet. Chem. 690, 2548 (2005).

43. Pancratistatin causes early activation of caspase-3 flipping of phosphotidyl serine followed by rapid apoptosis specifically in human lymphoma cells. S. Pandey,* N. Kekre, J. McNulty, J. Naderi, Cancer Chemotherapy and Pharmacology, 56, 29 (2005).

42. Phosphonium Salts as Room-Temperature Ionic Liquids in Organic Synthesis. J. McNulty,* A. Capretta, S. Cheekoori, J.A.C. Clyburne, A.J. Robertson, Chemicca Oggi, 22 (11/12), 13 (2004).

41. Phospha-adamantanes as Ligands for Organopalladium Chemistry: Aminations of Aryl Halides. D.A. Gerritsma, T. Brenstrum, J. McNulty and A. Capretta,* Tetrahedron Lett., 45, 8319 (2004).

40. Phospha-adamantanes as Ligands for Palladium Catalyzed Cross-Coupling Chemistry: Library Synthesis, Characterization and Screening in the Suzuki Coupling of Alkyl Halides and Tosylates Containing b-Hydrogens with Boronic Acids and Alkylboranes. T. Brenstrum, D. A. Gerristma, G.M. Adjabeng, C. S. Frampton, J. Britten, A. J. Robertson, J. McNulty, and A. Capretta. Journal of Organic Chemistry, 69, 7635 (2004).

39. Heck Reactions of Aryl Halides in Phosphonium Salt Ionic Liquids: Library Screening and Applications. D.A. Gerritsma, A. Robertson, J. McNulty and A. Capretta. Tetrahedron Letters, 45, 7629 (2004).

38. Palladium Complexes of 1,3,5,7-tetramethyl-2,4,8-Trioxa-6-Phenyl-6- Phospha-adamantane: Synthesis, Crystal Structure and Use in the Suzuki and Sonogashira Reactions and the α-Arylation of Ketones. G. Adjabeng, T. Brenstrum, C.S. Frampton, A.J. Robertson, J. Hillhouse, J. McNulty, A. Capretta, J. Org. Chem., 69, 5082 (2004).

37. Solid-Phase Suzuki Cross-Coupling Reactions Using a Phosphine Ligand Based on a Phoshpa-adamantane Framework. S.A. Ohnmacht, T. Brenstrum, K.H. Bleicher, J. McNulty, A. Capretta, Tetrahedron Lett., 45, 5661 (2004).

36. Antineoplastic Agents 491. Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine aand 4-Methylaaptamine. G.R. Pettit, H. Hoffman, D.L. Herald, J. McNulty, A. Murphy, K.C. Higgs, E. Hamel, N.E. Lewin, L.V. Pearce, P.M. Blumberg, R.K. Pettit, J.C. Knight, J. Org. Chem., 69, 2251 (2004).

35. Antineoplastic Agents 380. Isolation and X-ray Crystal Structure Determination of Isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the Phosphate Prodrug Hystatin 1. G.R. Pettit, H. Hoffman, J. McNulty, K.C. Higgs, A. Murphy, D.J. Molloy, D.L. Herald, M.D. Williams, R.K. Pettit, D.L. Doubek, J.N.A. Hooper, L. Albright, J.M. Schmidt, J.C. Chapuis, L. P. Tackett. J. Nat. Prod., 67, 506 (2004).

34. Regiocontrol in the NBS-Mediated Oxidative Radical Fragmentation of Benzilidene Acetals and its Mechanistic Implications. J. McNulty, J. Wilson, A. Rochon, J. Org. Chem., 69, 563 (2004).

33. A Highly Efficient General Synthesis of Phosphine-Borane Complexes. J. McNulty, Y. Zhou, Tetrahedron Lett., 45, 407 (2004).

32. Phosphonium Salt Catalyzed Carbonyl Addition Reactions. J. McNulty, J. Dyck, V. Larichev, A. Capretta, A.J. Robertson, Lett. in Org. Chem., 1, 137 (2004).

31. The Role of Acyloxyphosphonium Ionas and Stereochemical Influence of Base in the Phosphorane-Mediated Esterification of Alcohols. J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, Angew. Chem. Int. Ed., 42, 4051 (2003) [Angew. Chem. 115, 4185 (2003)].

30. Dimethylmalonyltrialkylphosphoranes: New general reagents for esterification Reactions Allowing Controlled Inversion or Retention of Configuration on Chiral Alcohols. J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, J. Org. Chem., 68, 1597 (2003).

29. Novel Class of tertiary Phosphine Ligands based on a Phospha-adamantane Framework and use in the Suzuki Reaction of Aryl Halides Under Mild Conditions. G. Adjabeng, T. Brenstrum, J. Wilson, C. Frampton, A.J. Robertson, J. Hillhouse, J. McNulty, A. Capretta, Org. Lett., 5, 953 (2003).

28. Lipase Catalyzed Stereoselective Resolution and Desymmetrization of Binapthols. M. Juarez-Hernandez, D.V. Johnson, H.L. Holland, J. McNulty, A. Capretta, Tetrahedron Asymm., 14, 289 (2003).

27.Suzuki Cross-coupling Reactions of Aryl halides in phosphonium Salt Ionic Liquid Under Mild Conditions. J. McNulty, A. Capretta, J. Wilson, J. Dyck, G. Adjabeng, A.J. Robertson, J. Chem. Soc., Chem. Commun., 1986 (2002).

26.A New Class of Phosphorane for Condensation Reactions. J. McNulty, A. Capretta, V. Larichev, J. Dyck, A.J. Robertson, US and International patents pending; WO 2004/000778 A1.

25. On the Direct 2,3-Hydroxyl Group Differentiation of Tartaric Acid Esters. J. McNulty, J. Mao, Tetrahedron lett., 43, 3857 (2002).

24. A New Structural Motif for Rigid C2-Symmetrical 1,2-Diamines Employing Double Intramolecular pi-Stacking. J. McNulty, R. Mo, A. Capretta, C.S. Frampton, J. Chem. Soc., Chem. Commun., 2384 (2001).

23. Studies Directed Towards the Refinement of the Pancratistatin Cytotoxic Pharmacophore. J. McNulty, J. Mao, R. Gibe, R. Mo, S. Wolf, G.R. Pettit, D.L. Herald, M.R. Boyd, Bioorganic and Med. Chem. Lett., 11, 169 (2001).

22. Selective Addition of grignard Reagents to 2,3-O-isopropylidene-bis Weinreb tartaric Acid Amides. J. McNulty, V. Grunner, J. Mao, Tetrahedron lett., 42, 5609 (2001).

21. Novel Chiral phosphines derived from Limonene: the Synthesis and Structure of 4,8-Dimethyl-2-phosphabicyclo[3.3.1]nonane. A.J. Robertson, C. Bradaric, C.S. Frampton, J. McNulty, A. Capretta, Tetrahedron Lett., 42, 2609 (2001).

20. Synthetic Approaches to the Eudistomin Marine Alkaloids. J. McNulty, I.W.J. Still, Current Org. Chem., 4, 121 (2000).

19. Stereoselective Oxidative Dimerization of (1R)-Camphor. A Short Synthesis of exo,exo'-3,3'-Biisoborneol. J. McNulty, M.J. Millar, G. Bernardinelli, C.W. Jefford, J. Org. Chem., 64, 5312 (1999).

18. The Ultrasound Promoted Knoevenagel Condensation of Aromatic Aldehydes. J. McNulty, J.A. Steere, S. Wolf, Tetrahedron let., 39, 8013 (1998).

17. Diastereoselective Intramolecular Entry to Lycoricidine Alkaloids. J. McNulty, R. Mo, J. Chem. Soc., Chem. Commun., 933 (1998).

16. Antineoplastic Agents. 362. Isolati x-ray crystal Structure of Dibromophakelstatin from the Indian Ocean Sponge Phakellia mauritiana. G.R. Pettit, J. McNulty, D.L. Herald, D.L. Doubek, J. Chapuis, J.M. Schmidt, L.P. Tackett, M.R. Boyd., J. Nat. Prod., 60, 180 (1997).

15. Synthesis of Enantiomerically Pure Beta-Amino Acids from L- and D-aspartic Acids. C.W. Jefford, J. McNulty,, in Enantioselective Synthesis of Beta-Amino Acids, pp 83-104, E. Juaristi (Ed), Wiley, New York (1997).

14. The Enantioselective Synthesis of Beta-Amino Acids Their Alpha-Hydroxy Derivatives and the N-Terminal Components of Bestatin and Microginin. C.W. Jefford, J. McNulty, Z. Lu, J.B. Wang, Helvetica Chim. Acta., 79, 1203 (1996).

13. Selective Methylation and Stereoselective reduction of a beta-Carboline to a N(2)-Methyl-1,2,3,4-tetrahydro-Beta-Carboline. J. McNulty, I.W.J. Still, Tetrahedron Lett., 36, 7965 (1995).

12. Associative Behavior and Diffussion Coefficients of Hydrophobically Modified Poly(N,N-dimethylacrylamides). Y. Uemura, J. McNulty, P.M. Macdonald, Macromolecules, 28, 4150 (1995).

11. A Concise Enantioselective Synthessi of N-Morpholinosphingosines from D-Aspartic Acid. C.W. Jefford, J. McNulty, Z. Lu, J. Chem. Soc., Chem. Commun., 123 (1995).

10. Formamadine as a Versatile Protecting Group for Primary Amines: A Mild Procedure for Hydrolytic Removal. D. Toste, J. McNulty, I.W.J. Still, Synth. Commun., 24, 1617 (1994).

9. A Practical Synthesis of (2S,3R)-3-Amino-2-methylpentanoic Acid from L-Aspartic Acid. C.W. Jefford, J. McNulty, Helvetica Chim. Acta., 77, 2142 (1994).

8. Diastereoselective Pictet-Spengler Reactions of L-(Boc)Phenylalaninal and L-(Boc)Prolinal: Biomimetic Syntheses of Eudistomin T and (-)-Woodinine. J. McNulty, I.W.J. Still, J. Chem. Soc., Perkin Trans. 1, 1329 (1994).

7. Synthetic Approaches to the Eudistomins. J. McNulty, Ph.D. Thesis, University of Toronto (1993).

6. A Simple High-Yielding Synthesis of N(Boc) Alpha-Amino Esters: Precursors for Alpha-Amino Aldehydes. J. McNulty, I.W.J. Still., Synth. Commun., 22, 979 (1992).

5. Diastereoselective Pictet-Spengler Reactions of L-(Boc)Prolinal: A Biomimetic Synthesis of Eudistomins H and I and (-)-Woodinine. J. McNulty, I.W.J. Still, Tetrahedron Lett., 32, 4875 (1991).

4. A Comment on Uniform Polymer Particles by Dispersion Polymerization in Alcohol. A.J. Paine, J. McNulty, J. Polym. Sci.: Polym. Chem. Ed., 28, 2569 (1990).

3. Dispersion Polymerization of Styrene in Polar Solvents. 6. Influence of Reaction Parameters on Particle Size and Molecular Weight in Poly(N-vinylpyrrolidone)-Stabilized Reactions. A.J. Paine, W. Luymes, J. McNulty, Macromolecules, 23, 3104 (1990).

2. The Total Synthesis of Eudistomins S and T. J. McNulty, M.Sc. Thesis, University of Toronto (1989).

1. The Synthesis of Eudistomins S and T: Beta-carbolines from the Tunicate Eudistoma olivaceum. I.W.J. Still, J. McNulty, Heterocycles, 29, 2057 (1989).