Date/Time
Date(s) - 11/04/2022
1:30 pm - 2:30 pm

Title: ¹⁸F-labelled Rhodamine dyes: PET tracersfor imaging myocardial perfusion and the distribution of transplantedmitochondria

 Date: Monday,April 11, 2022

 Time: 1:30-2:30

We are offering this seminar in hybrid format.

Room: ABB 163

Zoom: Please email chemgrad@mcmaster.ca for Zoom details

 

Abstract: Rhodamines are fluorescent delocalized lipophilic cations that have high affinity for mitochondria and thus have been used extensively as potentiometric dyes for the study of these ‘powerhouses of the cell’ in vitro.

 

Heart cells are rich in mitochondria, and thus researchers at Boston Children’s Hospital (BCH) Radiopharmaceutical Research Lab have synthesized rhodamine-based nuclear imaging agents that can be used to evaluate myocardial perfusion and thus potentially detect coronary artery disease in vivo using positron emission tomography (PET) imaging.

 

The lecture will start with an introduction to PET and positron-emitting radioisotope fluorine-18 (¹⁸F), followed by a discussion of radiotracers useful for cardiovascular imaging applications.

 

The bulk of the lecture will detail the ongoing development of ¹⁸F-labelledrhodamines as myocardial perfusion imaging agents, including chemical and radiochemical synthesis, preclinical PET imaging, and first-in-human investigations of a promising ¹⁸F-PET tracer based on a Rhodamine 6Gscaffold.

 

The final section will detail the role of this ¹⁸Fprobe in the validation of autologous mitochondrial transplantation, a revolutionary treatment strategy that utilizes a patient’s own harvested mitochondria to preserve heart tissue that has been damaged by ischemia-reperfusion injury.