Date/Time
Date(s) - 25/04/2024
1:30 pm - 2:20 pm

Title: Combinatorial Design of Lipid Nanoparticles for Tissue-Specific mRNA Delivery

Date: Thursday April 25, 2024

Time: 1:30-2:20pm

Room: ABB 165

Host: Dr. Alex Adronov

Abstract: The ability to transfect selective cell types within the targeted tissue in vivo is critical for potential therapeutic applications of mRNA. Although great advances have been made in mRNA vaccines, the ideal chemical and formulation composition of lipid nanoparticles (LNPs) for extra-hepatic delivery of nucleic acids are largely unknown. The traditional development of new lipids and formulations has been challenging, given the complexity of biological systems. A “high throughput” approach can be valuable because many variables can simultaneously be tested. In this talk, I will introduce a high-throughput combinatorial platform where thousands of chemically diverse libraries of lipid-like materials can be rapidly synthesized using multicomponent reactions and formulated into LNPs, which can then be screened for tissue- or cell-specific gene delivery. This platform technology increases the diversity of synthetic material structures and facilitates the identification of structure-function relationships.