Department Seminar – Dr. James Inkster, Research Associate, Department of Chemistry, University of Saskatchewan
Apr 11, 2022
1:30PM to 2:30PM
Date(s) - 11/04/2022
1:30 pm - 2:30 pm
Title: 18F-labelled Rhodamine dyes: PET tracersfor imaging myocardial perfusion and the distribution of transplantedmitochondria
Date: Monday,April 11, 2022
We are offering this seminar in hybrid format.
Room: ABB 163
Zoom: Please email firstname.lastname@example.org for Zoom details
Abstract: Rhodamines are fluorescent delocalized lipophilic cations that have high affinity for mitochondria and thus have been used extensively as potentiometric dyes for the study of these ‘powerhouses of the cell’ in vitro.
Heart cells are rich in mitochondria, and thus researchers at Boston Children’s Hospital (BCH) Radiopharmaceutical Research Lab have synthesized rhodamine-based nuclear imaging agents that can be used to evaluate myocardial perfusion and thus potentially detect coronary artery disease in vivo using positron emission tomography (PET) imaging.
The lecture will start with an introduction to PET and positron-emitting radioisotope fluorine-18 (18F), followed by a discussion of radiotracers useful for cardiovascular imaging applications.
The bulk of the lecture will detail the ongoing development of 18F-labelledrhodamines as myocardial perfusion imaging agents, including chemical and radiochemical synthesis, preclinical PET imaging, and first-in-human investigations of a promising 18F-PET tracer based on a Rhodamine 6Gscaffold.
The final section will detail the role of this 18Fprobe in the validation of autologous mitochondrial transplantation, a revolutionary treatment strategy that utilizes a patient’s own harvested mitochondria to preserve heart tissue that has been damaged by ischemia-reperfusion injury.