Chemical Biology Is The Application Of Chemistry To Solve Biological Problems.
Chemical Biology at McMaster applies chemical techniques and tools to study and manipulate of biological systems. This includes studying interactions between small molecules and macromolecules (proteins and nucleic acids), and molecules of all sizes (polymers) with biological systems, including cells and whole organisms. Much of this work involves preparing, characterizing and delivering compounds (from small molecules all the way to antibodies) that might be used as drugs or diagnostics. We synthesize new complexing agents to deliver transition metals to specific organs in the body for use in radio-imaging such as MRI, PET scans, and other medical applications. We also develop analytical techniques for metabolomics research, and biosensors to rapidly diagnose infections.
Areas of specialty include:
Professor, Associate Chair (Undergraduate Studies)
Research focuses on: Transition-state analysis, enzyme inhibition, inhibitor design, enzyme mechanisms
Professor, Canada Research Chair in Point-of-Care Diagnostics
Professor
Research focuses on: Bioanalytical chemistry; metabolomics; exposomics; biomarker discovery; clinical biochemistry; capillary electrophoresis; mass spectrometry; chemometrics; bimolecular interactions; drug screening; newborn screening; population health; nutrition; precision health
Assistant Professor
Research focuses on:DNA Nanotechnology, Supramolecular DNA Assembly, Spherical Nucleic Acids, Chemical Biology
Associate Professor
Professor Emeritus
http://unicorn.mcmaster.ca/
Professor, Departments of Biochemistry & Biomedical Sciences and Chemistry & Chemical Biology
Associate Professor, Departments of Biochemistry & Biomedical Sciences and Chemistry & Chemical Biology
Associate Professor, Department of Biochemistry & Biomedical Sciences
Research focuses on: Organic Synthesis; Medicinal Chemistry; Natural Products; Organocatalysis; Transition-metal Catalysis;Total Synthesis
Professor and Chair
Research focuses on: Pre-clinical molecular pharmacology of neurodegenerative diseases and cancer; intrinsically unstructured amyloidogenic proteins: protein kinases & signaling; functional protein dynamics and allosteric regulation; Nuclear Magnetic Resonance (NMR)
Our research program aims to use novel methods to understand how chemical exposure and other environmental factors influence human and ecosystem health. Our areas of investigation include:
Associate Professor, Department of Medicine
Research focuses on: Molecular imaging, radiolabeling methodologies, targeted radiotherapeutics, preclinical in vitro and in vivo validation of radiopharmaceuticals, clinical translation
Associate Professor, Director of Chemical Biology (Graduate Studies)
Research focuses on: Delivery vehicles, controlled release, immunotherapeutics, immune-directing polymer coatings
The Wylie Lab develops protein-polymer conjugates for: 1. Delivery of biologics, primarily polymer-antibody conjugates, for applications in cancer immunotherapy and degenerative retinal diseases 2. Bioreactors to modulate blood chemistry towards the treatment of sepsis 3. Bio-inks for the 3D printing of tissues to improve drug screening efficiency Please visit wylielab.com for more information.